Abstract: 12.20 The Mif Superfamily In Adipose Tissue Inflammation And Wound Repair

intRoduCtion: Impaired wound repair represents a major health risk and a substantial burden to healthcare systems worldwide. While the factors that may facilitate wound repair may be manifold, subcutaneous adipose tissue plays a central, yet underappreciated role as it is a dynamic organ situated in immediate proximity to the skin and participates in wound repair inter alia by the secretion of soluble factors. The macrophage migration inhibitory factor (MIF) is a pro-inflammatory cytokine that was earlier described in the context of chronic adipose tissue inflammation. D-dopachrome tautomerase (DDT, MIF-2) was only recently added to the MIF protein superfamily and although its exact functions are unknown, DDT is considered a functional homologue of MIF. The purpose of the present study was to investigate the expression of adipose tissuederived MIF and DDT in wound healing disorders and elucidate their functions on dermal fibroblasts and cell mobilization.